Velpanex 400 Mg & 100 Mg
Velpanex 400 mg & 100 mg (Sofosbuvir & Velpatasvir) is a revolutionary fixed-dose combination tablet indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) infection. This potent antiviral therapy is effective against multiple HCV genotypes and offers hope to millions of individuals suffering from this liver-damaging disease. In this comprehensive guide, we will explore the pharmacology, dosage, administration, interactions, side effects, and precautions of Velpanex, shedding light on its potential benefits and considerations during pregnancy and lactation.
Description
Velpanex is an oral medication that combines two vital antiviral agents: Sofosbuvir and Velpatasvir. Each component targets specific proteins essential for the HCV replication process, making this combination highly effective in suppressing the virus and achieving sustained virological response (SVR).
1. Sofosbuvir: Sofosbuvir belongs to the class of nucleotide analog HCV NS5B polymerase inhibitors. By mimicking the viral RNA building blocks, Sofosbuvir disrupts the replication process, leading to a significant reduction in viral load.
2. Velpatasvir: Velpatasvir is an NS5A inhibitor that hinders the assembly and maturation of new HCV virions. Its mechanism of action complements Sofosbuvir, ensuring a higher barrier to resistance and broader efficacy against various HCV genotypes.
The recommended dosage of Velpanex is one tablet containing 400 mg of Sofosbuvir and 100 mg of Velpatasvir, to be taken orally once daily. The treatment duration may vary based on the patient’s cirrhosis status:
1. Patients without cirrhosis and patients with compensated cirrhosis (Child-Pugh A): The standard treatment duration is 12 weeks with one tablet daily.
2. Patients with decompensated cirrhosis (Child-Pugh B or C): The recommended treatment involves one tablet daily in combination with Ribavirin for 12 weeks. The Ribavirin dosage is based on the patient’s body weight and is divided into two daily doses.
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